Activity Assay:Article Title: The antimicrobial potential of cannabidiol
Article Snippet: .. Where an FICI value is not displayed one could not be calculated as there was no relevant inhibitory activity to record, i.e. either CBD inactive >64 μg mL-1 or concentration was equal to the MIC of polymyxin B. CBD MIC (μg mL-1) with PMBN at conc (μg mL-1) of PMBN MIC (μg mL-1 ) Antibiotic Species Strain/ Description CBD MIC (μg mL-1) 32 16 8 4 2 1 PMBN Escherichia coli ATCC 25922 FDA control >256 64 64 64 64 64 64 >32 >256 64 >256 >256 >256 64 64 >32 >256 64 64 64 64 >256 >256 >32 >256 64 64 >256 >256 >256 >256 >32 Klebsiella pneumoniae ATCC 700603 ESBL >256 64 >256 >256 >256 >256 >256 >32 >256 32 32 32 64 >256 >256 >32 >256 >256 >256 >256 >256 >256 >256 >32 >256 >256 >256 >256 >256 >256 >256 >32 Acinetobacter baumannii ATCC 19606 Type strain >256 32 32 32 32 32 32 >32 >256 32 32 32 32 32 32 >32 >256 32 32 32 32 64 >256 >32 >256 32 32 32 32 64 64 >32 Pseudomonas aeruginosa ATCC 27853 QC strain >256 32 64 64 64 64 64 >32 >256 32 32 32 32 64 64 >32 >256 16 32 64 32 32 >256 >32 >256 16 32 64 32 32 >256 >32 The grey/yellow shaded values indicate synergy, where synergy is defined by FICI value of ≤0.5. .. Where no value is given, CDB concentration is irrelevant as the combination is at the MIC concentration of polymyxin B. CBD with PMBN FICI values Antibiotic Species Strain/Description 32 16 8 4 2 1 PMBN Escherichia coli ATCC 25922 FDA control 1.25 0.75 0.5 0.375 0.3125 0.281 1.25 1.5 1.25 1.125 0.3125 0.281 1.25 0.75 0.5 0.375 1.062 1.031 1.25 0.75 1.25 1.125 1.062 1.031 Klebsiella pneumoniae ATCC 700603 ESBL 1.25 1.5 1.25 1.125 1.062 1.031 1.125 0.625 0.375 0.375 1.062 1.031 2 1.5 1.25 1.125 1.062 1.031 2 1.5 1.25 1.125 1.062 1.031 Acinetobacter baumannii ATCC 19606 Type strain 1.125 0.625 0.375 0.25 0.188 0.156 1.125 0.625 0.375 0.25 0.188 0.156 1.125 0.625 0.375 0.25 0.312 1.031 1.125 0.625 0.375 0.25 0.312 0.281 Pseudomonas aeruginosa ATCC 27853 QC strain 1.125 0.75 0.5 0.375 0.312 0.281 1.125 0.625 0.375 0.25 0.312 0.281 1.062 0.625 0.5 0.25 0.187 1.031 1.062 0.625 0.5 0.25 0.187 1.031 FICI scores were calculated using an MIC of 64 μg mL-1 for cannabidiol.
Concentration Assay:Article Title: The antimicrobial potential of cannabidiol
Article Snippet: .. Where an FICI value is not displayed one could not be calculated as there was no relevant inhibitory activity to record, i.e. either CBD inactive >64 μg mL-1 or concentration was equal to the MIC of polymyxin B. CBD MIC (μg mL-1) with PMBN at conc (μg mL-1) of PMBN MIC (μg mL-1 ) Antibiotic Species Strain/ Description CBD MIC (μg mL-1) 32 16 8 4 2 1 PMBN Escherichia coli ATCC 25922 FDA control >256 64 64 64 64 64 64 >32 >256 64 >256 >256 >256 64 64 >32 >256 64 64 64 64 >256 >256 >32 >256 64 64 >256 >256 >256 >256 >32 Klebsiella pneumoniae ATCC 700603 ESBL >256 64 >256 >256 >256 >256 >256 >32 >256 32 32 32 64 >256 >256 >32 >256 >256 >256 >256 >256 >256 >256 >32 >256 >256 >256 >256 >256 >256 >256 >32 Acinetobacter baumannii ATCC 19606 Type strain >256 32 32 32 32 32 32 >32 >256 32 32 32 32 32 32 >32 >256 32 32 32 32 64 >256 >32 >256 32 32 32 32 64 64 >32 Pseudomonas aeruginosa ATCC 27853 QC strain >256 32 64 64 64 64 64 >32 >256 32 32 32 32 64 64 >32 >256 16 32 64 32 32 >256 >32 >256 16 32 64 32 32 >256 >32 The grey/yellow shaded values indicate synergy, where synergy is defined by FICI value of ≤0.5. .. Where no value is given, CDB concentration is irrelevant as the combination is at the MIC concentration of polymyxin B. CBD with PMBN FICI values Antibiotic Species Strain/Description 32 16 8 4 2 1 PMBN Escherichia coli ATCC 25922 FDA control 1.25 0.75 0.5 0.375 0.3125 0.281 1.25 1.5 1.25 1.125 0.3125 0.281 1.25 0.75 0.5 0.375 1.062 1.031 1.25 0.75 1.25 1.125 1.062 1.031 Klebsiella pneumoniae ATCC 700603 ESBL 1.25 1.5 1.25 1.125 1.062 1.031 1.125 0.625 0.375 0.375 1.062 1.031 2 1.5 1.25 1.125 1.062 1.031 2 1.5 1.25 1.125 1.062 1.031 Acinetobacter baumannii ATCC 19606 Type strain 1.125 0.625 0.375 0.25 0.188 0.156 1.125 0.625 0.375 0.25 0.188 0.156 1.125 0.625 0.375 0.25 0.312 1.031 1.125 0.625 0.375 0.25 0.312 0.281 Pseudomonas aeruginosa ATCC 27853 QC strain 1.125 0.75 0.5 0.375 0.312 0.281 1.125 0.625 0.375 0.25 0.312 0.281 1.062 0.625 0.5 0.25 0.187 1.031 1.062 0.625 0.5 0.25 0.187 1.031 FICI scores were calculated using an MIC of 64 μg mL-1 for cannabidiol.
Control:Article Title: The antimicrobial potential of cannabidiol
Article Snippet: .. Where an FICI value is not displayed one could not be calculated as there was no relevant inhibitory activity to record, i.e. either CBD inactive >64 μg mL-1 or concentration was equal to the MIC of polymyxin B. CBD MIC (μg mL-1) with PMBN at conc (μg mL-1) of PMBN MIC (μg mL-1 ) Antibiotic Species Strain/ Description CBD MIC (μg mL-1) 32 16 8 4 2 1 PMBN Escherichia coli ATCC 25922 FDA control >256 64 64 64 64 64 64 >32 >256 64 >256 >256 >256 64 64 >32 >256 64 64 64 64 >256 >256 >32 >256 64 64 >256 >256 >256 >256 >32 Klebsiella pneumoniae ATCC 700603 ESBL >256 64 >256 >256 >256 >256 >256 >32 >256 32 32 32 64 >256 >256 >32 >256 >256 >256 >256 >256 >256 >256 >32 >256 >256 >256 >256 >256 >256 >256 >32 Acinetobacter baumannii ATCC 19606 Type strain >256 32 32 32 32 32 32 >32 >256 32 32 32 32 32 32 >32 >256 32 32 32 32 64 >256 >32 >256 32 32 32 32 64 64 >32 Pseudomonas aeruginosa ATCC 27853 QC strain >256 32 64 64 64 64 64 >32 >256 32 32 32 32 64 64 >32 >256 16 32 64 32 32 >256 >32 >256 16 32 64 32 32 >256 >32 The grey/yellow shaded values indicate synergy, where synergy is defined by FICI value of ≤0.5. .. Where no value is given, CDB concentration is irrelevant as the combination is at the MIC concentration of polymyxin B. CBD with PMBN FICI values Antibiotic Species Strain/Description 32 16 8 4 2 1 PMBN Escherichia coli ATCC 25922 FDA control 1.25 0.75 0.5 0.375 0.3125 0.281 1.25 1.5 1.25 1.125 0.3125 0.281 1.25 0.75 0.5 0.375 1.062 1.031 1.25 0.75 1.25 1.125 1.062 1.031 Klebsiella pneumoniae ATCC 700603 ESBL 1.25 1.5 1.25 1.125 1.062 1.031 1.125 0.625 0.375 0.375 1.062 1.031 2 1.5 1.25 1.125 1.062 1.031 2 1.5 1.25 1.125 1.062 1.031 Acinetobacter baumannii ATCC 19606 Type strain 1.125 0.625 0.375 0.25 0.188 0.156 1.125 0.625 0.375 0.25 0.188 0.156 1.125 0.625 0.375 0.25 0.312 1.031 1.125 0.625 0.375 0.25 0.312 0.281 Pseudomonas aeruginosa ATCC 27853 QC strain 1.125 0.75 0.5 0.375 0.312 0.281 1.125 0.625 0.375 0.25 0.312 0.281 1.062 0.625 0.5 0.25 0.187 1.031 1.062 0.625 0.5 0.25 0.187 1.031 FICI scores were calculated using an MIC of 64 μg mL-1 for cannabidiol.
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